Situated along the historic Cheyenne-Deadwood stagecoach route, it had a front-row seat to the Black Hills Gold Rush of the 1870s and '80s. Similarly, as a station on the Fremont, Elkhorn, and Missouri Valley Railroad, Lusk was a destination for gold, silver, copper, and uranium miners seeking their fortune. It also enjoyed an oil boom in the early 1900s.
Today, Lusk is the heart of the Wyoming Quilt Trail, as well as the home of the Legend of Rawhide Pageant, held every July.